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Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. In this review, we focus on the regulatory mechanism of ectodomain shedding by ADAM10/17 metalloprotease via GPCR signaling. PAR2 and NK1R induce membrane blebbing, resulting in phosphatidylserine externalization in the cellular membrane, which is required for ADAM10/17 metalloprotease activation.
Roles of NS1 Protein in Flavivirus Pathogenesis
A model for ectodomain shedding and secretion of DPF. DPF is
Frontiers Metabolic Functions of G Protein-Coupled Receptors and β-Arrestin-Mediated Signaling Pathways in the Pathophysiology of Type 2 Diabetes and Obesity
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Ontogeny, Anatomy, Metabolism and Physiology of the Thyroid - Endotext - NCBI Bookshelf
Intercellular signaling by ectodomain shedding at the synapse: Trends in Neurosciences
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
TRIM28/TIF1β and Fli-1 negatively regulate peroxynitrite generation via DUOX2 to decrease the shedding of membrane-bound fractalkine in human macrophages after exposure to substance P - ScienceDirect
Analysis of CERK1 ectodomain shedding and the role of XLG2 in cerk1-4 cell death execution